The purpose of this study was to synthesize (E)-2-benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones and investigate their larvicidal potential against Anopheles stephensi and Hippobosca maculata. Synthetic acridines are used in many commercial applications. The results obtained from FTIR, 1H and 13C NMR, and ESI-MS spectra confirm the synthesis of (E)-2-benzylidene-7-chloro-9-phenyl-3,4-dihydroacridin-1(2H)-ones, 3a-j. Larvae were exposed to different concentrations of compounds, 3a-j for 24 h. All the compounds had moderate activity; maximum efficacy was observed for 3e and 3j. © 2013 Springer Science+Business Media Dordrecht.