Fluconazole is a synthetic triazole antifungal agent used in treating many fungal infections. Owing to its poor aqueous solubilization property, we focused at devising a simple microemulsion drug delivery system for fluconazole comprising of clove oil, tween 20 and water (5: 30: 65 wt/wt). Several parameters like conductivity, pH, viscosity and droplet size measurements were done to optimize the formulated microemulsion. The drug incorporated microemulsion measured about 8-20 nm by dynamic light scattering method. The particle size reduction of the drug would prove in improving the efficacy and stability of the drug in-vivo as compared to its bulk form. Thus, this formulation acts as a suitable oral drug delivery system with bio-safety.