In Recent times Nano particles have been used in juice and food industries without proper basic information about their harm ful nature. Few inventions proved the uptake and disposition of nano particles by the Digestive and Gastro intestinal tract pose problem and there are research investigations where they cross the lining of the Gastro and intestinal tract and circulate in the blood stream, from where they adhere to other body organs and systems. In vitro and In vivo studies with different types of nanoparticles titanium dioxide, metal/metal oxide carbon nano tubes and silica; but not other nonmaterial's on various cell lines (Hepatic and lung) have demonstrated a variety of oxidative stress-related to immunological and inflammatory reactions. In this study we have postulated that this response is driven by the specific surface area of the nanoparticle and/or its chemical composition, biological synthesis by actinobacteria (microbial), Nano mission etc will be envisaged.