The exponential growth in computational speed and storage capabilities has opened a new era in biological analysis of data. Bioinformaticswith itscontinually evolving tools have become indispensable in biological research. Bioinformatics changes large amounts of existing data into information that can be used to facilitate new discoveries in biology . At present research in bioinformatics can be classified into (1) genome studies, (2) proteomics, (3) cell visualization and simulation and (4) application to the development of drugs . Current Important approaches in bioinformatics research are(1) analysis based on wet -lab data,(2) finding new results from mathematical modeling, (3)an integrated approach that integrates mathematical modeling with search techniques. The current bioinformatic tools have a potential to develop vaccine and drugs, to know the causeof diseases at molecular level, to develop low cost biological agents for bioremediation. Here are the current roles of bioinformatics, on the other hand bioinformatics software tools and resources are reviewed. © 2015, Sphinx Knowledge House. All rights reserved.