Wide use of wireless sensors in medical services has given rise to another field called wireless body area networks (WBANs). WBANs consist of networks of wearable or implanted sensors that continuously capture and measure the vital parameters of the body. These sensor nodes have limited resources in terms of processing power, battery, and memory. Thus, the use of power has to be controlled for prolonging the network lifetime of WBAN systems. For this purpose, various energy-efficient protocols and their respective energy optimization techniques were developed to optimize power consumption, which consequently results in high energy efficiency. This article explores a power optimizationmodel of three low-power routing protocols, namely, mobility-supporting adaptive threshold based thermal-aware energy-efficient multi-hop protocol (M-ATTEMPT), MBSTAR, and distance aware relaying energy-efficient (DARE), forWBAN. These protocols are implemented on three different test beds, and their conserved energy is compared for a varying number of sensors. Test beds were equipped with an ARM7 processor with different transceivers, namely, Bluetooth, Zigbee, and Wi-Fi. These protocols were implemented with varying transceivers taken for local case studies. Results are analyzed for the uniqueness of each protocol and their potential to support quick development and deployment of low-power WBAN systems. © 2019 by ASTM International.