In this paper, a delay-dependent anti-windup compensator is designed for wide-Area power systems to enhance the damping of inter-Area low-frequency oscillations in the presence of time-varying delays and actuator saturation using an indirect approach. In this approach, first, a conventional wide-Area damping controller is designed by using H output feedback with regional pole placement approach without considering time-varying delays and actuator saturation. Then to mitigate the effect of both time-varying delays and actuator saturation, an add-on delay-dependent anti-windup compensator is designed. Based on generalized sector conditions, less conservative delay-dependent sufficient conditions are derived in the form of a linear matrix inequality LMI to guarantee the asymptotic stability of the closed-loop system in the presence of time-varying delays and actuator saturation by using Lyapunov-Krasovskii functional and Jensen integral inequality. Based on sufficient conditions, the LMI-based optimization problem is formulated and solved to obtain the compensator gain which maximizes the estimation of the region of attraction and minimizes the upper bound of L2-gain. Nonlinear simulations are performed first using MATLAB Simulink on a two-Area four-machine power system to evaluate the performance of the proposed controller for two operating conditions, e.g., 3-phase to ground fault and generator 1 terminal voltage variation. Then the proposed controller is implemented in real-Time on an OPAL-RT digital simulator. From the results obtained it is verified that the proposed controller provides sufficient damping to the inter-Area oscillations in the presence of time-varying delays and actuator saturation and maximizes the estimation of the region of attraction. © 2014 Chinese Association of Automation.