A series of the diaryl ureas were synthesized from aryl amines by phosgene free protocol. They were screened for their anti microbial activity. The anti microbial activities were not promising towards all the tested organisms. But the compound 3h and 3k were shown comparable activity against Proteus mirabilis with respect to the standard ciprofloxacin. © 2018, Chiang Mai University. All rights reserved.