From a strategic point of view, the most valuable assets in the present era are knowledge assets. Effective management of knowledge assets is essential to use existing knowledge bases as well as to create new knowledge bases by knowledge workers. Therefore, knowledge assets and knowledge workers are crucial aspects of any Knowledge Management (KM) Framework. Most of the researchers have viewed knowledge management either from technical or management perspectives. From architectural perspectives either a centralized or a peer-to-peer approach has been mentioned in the literature. We present a holistic view of knowledge management considering its multiple dimensions and stakeholders to achieve specific organizational knowledge vision and goals. In this paper, we propose a five-layer knowledge management framework comprising of knowledge vision, knowledge processes and services, knowledge networks, knowledge asset management, and knowledge assets. Also, we describe an architecture for interaction among knowledge workers.