The objective of this work is to design and construct a low cost Electromyogram (EMG) and Electrooculogram (EOG) signal conditioning system for assistive device applications. The proposed circuit is designed for capturing surface EMG signal and EOG signal available on the surface of the human skin. This paper describes the system containing two units: signal detection unit and signal conditioning unit. The developed electronic circuit is also interfaced with PC-based data acquisition and analysis software LABVIEW for recording of signals. The recorded EMG and EOG signal may be further analysed and correlated with the control of assistive devices. It is proposed to use the results for study of man-machine interaction such as development of control for assistive devices.