Olmesartan is the recommended antihypertensive drug used in recent years. But due to its poor aqueous solubility and relatively low oral bioavailability, we intended to develop a clove oil based oil-in-water microemulsion system using conventional titration technique owing to its biocompatibility with minimal toxicity. This system showed good thermodynamic stability and reduced droplet size in the nanometer range and hence could reach blood capillaries and would serve as excellent drug delivery system for olmesartan. © 2014, Sphinx Knowledge House. All rights reserved.