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A nanoemulsion drug delivery system for an aqueous insoluble drug: Ultrasonication technique for ramipril preparation
Published in Sphinx Knowledge House
2014
Volume: 6
   
Issue: 3
Pages: 2020 - 2022
Abstract
Nanoemulsions have emerged as potential drug delivery systems for most hydrophobics in recent pharmaceutics. An angiotensin converting enzyme inhibitor, ramipril, of its kind has demonstrated relatively low aqueous solubility and bioavailability. This preferred medicine for hypertension and congestive heart failure has exhibited intense drug interactions leading to multiple side effects. Focusing on these facts, we intended to raise an essential oil based nanoemulsion comprising of cinnamon oil, tween 80 and water by ultrasonication. Stability studies were performed to delineate the best formulation. Droplet size analysis using dynamic light scattering technique and electrical conductivity was measured in characterizing the internal physico-chemical state of the emulsion. The optically clear and low-viscous formulation with enhanced solubility and minimum droplet size diameter would pose a definite promise in improving the significance of this sparingly soluble drug.
About the journal
JournalInternational Journal of ChemTech Research
PublisherSphinx Knowledge House
ISSN09744290