This manuscript is mainly focusing on the approximate controllability of fractional differential evolution inclusions of order 1 < r < 2 with infinite delay. We study our primary outcomes by using the theoretical concepts about fractional calculus, cosine, and sine function of operators and Dhage's fixed point theorem. Initially, we prove the approximate controllability for the fractional evolution system. The results are established under the assumption that the associated linear system is approximately controllable. Then, we develop our conclusions to the ideas of nonlocal conditions. Finally, we present theoretical and practical applications to support the validity of the study. © 2020 Elsevier Ltd