We have prepared biocompatible composites of 80wt% polyvinyl alcohol (PVA)-(20wt%) polyvinylpyrrolidone (PVP) blend with different concentrations of bioactive nanohydroxyapatite, Ca10(PO4)6(HO)2 (HAP). The composite films demonstrated maximum effective conductivity (σ∼1.64×10(-4)S/m) and effective dielectric constant (ε∼290) at percolation threshold concentration (∼10wt% HAP) at room temperature. These values of σ and ε are much higher than those of PVA, PVP or HAP. Our preliminary observation indicated excellent biocompatibility of the electrospun fibrous meshes of two of these composites with different HAP contents (8.5 and 5wt% within percolation threshold concentration) using NIH 3T3 fibroblast cell line. Cells viability on the well characterized composite fibrous scaffolds was determined by MTT [3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay analysis. Enhancement of σ, due to HAP addition, was found to show increased biocompatibility of the fibrous scaffold. Enhanced σ value of the PVA/PVP-HAP composite provided supporting cues for the increased cell viability and biocompatibility of the composite fibrous meshes. Excellent biocompatibility these electrospun composite scaffolds made them to plausible potential candidates for tissue engineering or other biomedical applications.

Sanjit Kumar

Centre for Bio-Separation and Technology

Vellore Campus

Chaudhuri B

Mondal B

Ray S.K

Sarkar S.C.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Colloids and Surfaces B: Biointerfaces

Zn-Mn HAP (Zinc and Manganese substituted Hydroxyapatite), CMC (Carboxymethyl cellulose)/PVP (Polyvinyl pyrrolidone) and (Zn-Mn HAP)/CMC/PVP (Zn = Mn = 0.05, 0.1 M) were prepared by hydrothermal and electrospinning methods respectively. The prepared composites were characterized using powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and Scanning Electron Microscopy (SEM) with Energy Dispersive X-Ray Analysis (EDAX) to examine the phase formation, functional groups and surface morphology. FTIR spectra of the composite confirmed the funcitonal groups present in the composite. SEM images showed the fiber formation and the incorporation of Zn-Mn HAP into the fiber structures. The physical properties like porosity, swelling and tensile strength was studied for the prepared composites. 0.1 M of (Zn-Mn HAP)/CMC/PVP (20, 40, 60 wt% of Zn-Mn HAP composite) showed good physical properties, in which the 60 wt% showed 98% of porosity with least swelling and the tensile strength was measured to be 67 MPa. Highest zone of inhibition was observed against the microbial organisms using this 60 wt% of 0.1 M of (Zn-Mn HAP)/CMC/PVP composite and it was also found to be hemocompatible with hemolysis value less than 3% when compared to other composites. The biocompatibility of the composite was evaluated using human osteoblast cells (HOS). © 2019 Elsevier B.V.

International Journal of Biological Macromolecules

Zinc and manganese substituted hydroxyapatite/CMC/PVP electrospun composite for bone repair applications

Cancellous bone region of the human native bone has the potential to bear significant mechanical loads. However, due to the following parameters such as low trabecular volume, more porosity, less thickness and more interconnectivity, cancellous bone is accessible to damage in accidents or when aging. This research led to the effective fabrication and engineering of cancellous region of the bone for its application in reconstruction or filling of bone voids after resection of large tumor mass. Scaffolds containing hydroxyapatite (HAp), polyvinyl alcohol (PVA) and polyvinyl pyrrolidone (PVP) (5% polymer and HAp concentrations) at different HAp: polymer composite ratios (50:50, 70:30 and 80:20), were fabricated by freeze–drying method using only water as solvent and ribose as crosslinker for the scaffolds. The fabricated scaffolds were characterized for its mechanical (compressive) strength, chemical properties using FT-IR and XRD analyses, swelling and degradation studies, confirmation of mineralization process by immersion in simulated body fluid (SBF) for 7, 15 and 30 days, morphological analysis using scanning electron microscopy (SEM), and biocompatibility properties by performing MTT analysis. From the combined interpretation of the above mentioned tests, it was proven that 80:20 ratio of HAp to polymers was found to be the most suitable scaffold in terms of its optimal properties for its use as bone graft material for trabecular bone. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3267–3274, 2018. © 2018 Wiley Periodicals, Inc.

Journal of Biomedical Materials Research Part A

Development of mechanically compliant 3D composite scaffolds for bone tissue engineering applications

Fulltext

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Biocompatibility of electrospun graphene oxide–poly(ε-caprolactone) fibrous scaffolds with human cord blood mesenchymal stem cells derived skeletal myoblast

A novel biocompatible conducting polyvinyl alcohol (PVA)-polyvinylpyrrolidone (PVP)-hydroxyapatite (HAP) composite scaffolds for probable biological application

Journal	Data powered by TypesetColloids and Surfaces B: Biointerfaces
Publisher	Data powered by TypesetElsevier BV
ISSN	0927-7765
Open Access	0