The objective of the Study is to comprehend the various global business expansion and related strategies implemented by three major retail companies in the three continents, namely the US, Europe and Asia Pacific. A number of empirical, review, conceptual articles and case studies were reviewed for global business strategy, followed by the evaluation of leading indicators and analyses of a number of National and International business research papers and articles. The key findings include that the successful global expansion includes thorough adaptation to the local business markets whose key constituents are customers, culture and customs, competition, and local laws. The article also includes the comparison of key parameters between three retail companies. The international business expansion for top retailers is also a challenging task when it comes to different market realities across continents. But, there are also successful global retailers whose presence is not bounded by continental geographies. The global retail industries are long-haul businesses with longer breakeven periods. So, an effective global business expansion strategy should be implemented with insight into the future business requirements. © IAEME Publication.