Breast cancer is growing among the women all over the world now a day. High cholesterol and obesity are important risk factors for cancer development. Many studies have suggested that our day to day dietary sources are rich in cholesterol ultimately leading to breast cancer. Cholesterol accelerates and enhances tumour formation. In addition, tumours are more aggressive and tumour angiogenesis is enhanced. The present study examined the role of cholesterol in the regulation of tumour progression in a model of mammary tumour formation. An association between high cholesterol and breast cancer has been found in study of more than 1 million patients over 14 year time. There are many studies done till date which suggests that there is some association found between high cholesterol and diseases, especially breast cancer. It is still to be confirmed that all cholesterol sources can lead to lifethreatening cancer. © 2015, Global Research Online. All rights reserved.