Agriculture with its associated divisions is undeniably the biggest occupation in all the regions of India and contributes a critical figure in Indian Gross Domestic Product. There are various types of farming in India. Agriculture in India is running towards a downtrend due to various reasons. Sustainable Natural Farming is the best eco-friendly and an essential idea in characteristic cultivating to keep up wellbeing of soil, products and different living life forms. It has diminishes reliance on constrained non-renewable assets, for example, petroleum based items and importation of natural materials. The technology advancement in Information and Communication is engineering is massive. Agro Informatics is an emerging research area, where various tools are research areas of Information and Communication Technology can be applied to enhance the various aspects of agriculture. This research article reviews the current challenges of Agriculture in India, the need for sustainable natural farming and the analysis on possible segments in Agriculture where Information and Communication Technology can concentrate. © 2016, International Journal of Pharmacy and Technology. All rights reserved.