This Paper presents a Single Phase Multilevel Inverter with DC-DC High Step UP (HSU) Converter for Photovoltaic (PV) System. Maximum Power Point Tracking (MPPT) assumes a noteworthy part in PV system since it expands the output power of PV system, for a given arrangement of condition and enhances the proficiency of the system. Perturb and observe is used to track the MPPT of the system.The DC-DC buck converter output voltage is 49.2V. To pick up the output voltage of 220V, a DC-DC HIGH Step UP (HSU) Converter is executed. Multilevel inverter is preferred for the proposed system, since it expands the aggregate number of output voltage levels with less number of switches. The Output voltage levels for Hybrid Multilevel inverter (HMLI) are +Vdc, +2Vdc/3, +Vdc/3, 0Vdc,-Vdc/3,-2Vdc/3,-Vdc. The Low switching frequency and High switching frequency (Multi reference Pulse width Modulation Technique (MRPWM)) is compared and its utilized to control the switches in the HMLI. The overall scheme is simulated by providing MATLAB/SIMULINK and the HMLI is done by utilizing PROTEUS programming and real time system.