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A Straightforward Metal-Free and Mild Base Promoted Amidation and Transesterification via Acyl C-O bond Cleavage-An Expedite Synthesis of Aromatic Amides and Esters
Shanmugam Karthik, Ramdas Sreedharan,
Published in Wiley
Volume: 4
Issue: 1
Pages: 175 - 180

A straight-forward and practical metal-free amidation and transesterification of esters have been exemplified in this protocol. This strategic reaction features mild bases and devoid of additives at a reasonable temperature (55 °C). The wide range of amines including aromatic amines, was successfully subjected to amidation that supplements the scope exploration. Likewise, various transesterification products from alcohols were realized under this optimized condition.

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PublisherData powered by TypesetWiley
Open Access0