Accumulation of high concentrations of heavy metals in soil and environment affects both humans and microorganisms. Heavy metals get accumulated within the tissues of the organism and at various levels of the ecological chain; leads to decrease in the biomass and biological diversity by affecting the growth, morphology, and activity of the organism. Removal of hazardous heavy metals and radionuclide-contamination through biological means is of current importance. Bioremediation using microorganisms is considered as safe and more efficient. Actinobacteria, the most important groups of microbes, are responsible for degradation and transformation of organic and metal substrates and also possess significant bioremediation potential. It can degrade high doses of pesticides, chemical complexes, and heavy metals. Actinomycetes utilise toxins as carbon sources and in turn synthesise commercially viable antibiotics, enzymes and proteins. In this review, the efficacy of actinomycetes in bioremediation of heavy metals such as copper, chromium, mercury, lead, zinc, and cadmium was discussed. Copyright © 2017 Inderscience Enterprises Ltd.