This article presents the calculation of the parameter extraction of photovoltaic (PV) panel using artificial immune system (AIS) and compared with genetic algorithm (GA) usingMATLAB, Simulink at different environmental conditions (for different irradiations (200–1000 w/m2)). The proposed method showing Ipv versus Vpv curves and to compare the obtained curve to the ideal values in order to obtain the absolute error curve. For extracting parameters of a PV cell, the proposed method useful because it can handle nonlinear functions. The proposed method compared with manual data and are validated by three different types of PV modules named as, Multi-crystalline (SHELL S36), Mono-crystalline (SHELL SP70) and Thin-film (SHELL ST40). Data derived from these calculations beneficial to decide the suitable computational technique to build an accurate and efficient simulators for a PV system.