A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) &amp; [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &amp; Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy &amp; time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence. © 2015 Elsevier Ltd. All rights reserved.

Priyankar Paira

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Vidya R

VIT School for Agricultural Innovations and Advanced Learning

Malipeddi M

Lakhani C

Chhabra M

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Bioorganic & Medicinal Chemistry Letters

IET Nanobiotechnology

Synthesis and studies of bay-substituted perylene diimide-based D–A–D-type SM acceptors for OSC and antimicrobial applications

A series of Ruthenium-Quinolinol complexes (3a–d &amp; 4a–d) has been synthesized by employing a simple, efficient and environmental friendly condition. Catalytic role of Amberlite IRA-120(H) has been demonstrated. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of these complexes was measured by UV spectroscopy &amp; time dependent NMR spectroscopy. These newly developed complexes were represented as potential anticancer agent against human breast carcinoma cell line (MCF-7), human Epitheloid Cervix Carcinoma (HeLa), human lung adenocarcinoma epithelial cell line (A549) and human colon cancer cell line (Caco-2). Most of the ruthenium complexes showed higher anticancer activity in MCF-7, HeLa and Caco-2 cell lines than cisplatin. A high selectivity (9–28 folds) was observed with these newly developed organoruthenium compounds in human cancer cell lines (MCF-7, HeLa and Caco-2) with respect to normal fibroblast cell line (MRC-5). Complex [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-HyQ)]·Cl (4b), [(η6-hexamethylbenzene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (4c) and [(η6-hexamethylbenzene)RuCl(κ2-O,N-5-chloro-7-iodo-HyQ)]·Cl (4d) exhibited best cytotoxicity profiles in three reported human cancer cell lines (MCF-7, HeLa, Caco-2). Cellular imaging study was also performed with these newly developed organoruthenium compounds. Compound 4c might be utilized for cancer theranostic agents because of its significant quantum yield in water, high potency, selectivity and high cellular uptake in cancer cell lines. © 2017

Journal of Photochemistry and Photobiology B: Biology

Amberlite IR-120 (H) mediated “on water” synthesis of fluorescent Ruthenium(II)-arene 8-hydroxyquinoline complexes for cancer therapy and live cell imaging

A novel three components approach for the synthesis of bioactive Ru-arene pyridinylmethylene complexes has been developed using pyridine carboxaldehyde, amino pyridine and dichloro (p-cymene) ruthenium(II) dimer as starting materials. These scaffolds were screened for their anticancer activity against breast cancer (MCF7) and human Epitheloid Cervix Carcinoma (HeLa) cell line. It was established that compounds [(η6-pcymene)RuCl(κ2-N,N-(3,5-dinitro-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4o), [(η6-pcymene)RuCl(κ2-N,N-N-(3,5-dibromo-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4c), [(η6-pcymene)RuCl(κ2-N,N-(3,5-dibromo-6-methylpyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4j) and [(η6-pcymene)RuCl(κ2-N,N-3(3-bromo-5-methyl-pyridin-2-yl)-pyridin-2-ylmethylene-amine)]PF6 (4b) were significantly active against both the cell lines. © 2016 Elsevier Ltd.All rights reserved.

Synthesis of novel anticancer ruthenium–arene pyridinylmethylene scaffolds via three-component reaction

A class of novel Ru(ii)–p-cymene BTZ, BOZ &amp; BIZ complexes have been synthesized “on water” using Amberlite IR-120(H) resin and their anticancer activities were evaluated.

New Journal of Chemistry

Amberlite IR-120(H)-mediated “on water” synthesis of novel anticancer ruthenium(ii)–p-cymene 2-pyridinylbenzothiazole (BTZ), 2-pyridinylbenzoxazole (BOZ) &amp; 2-pyridinylbenzimidazole (BIZ) scaffolds

Dalton Trans.

Structural characterization and biological evaluation of a clioquinol–ruthenium complex with copper-independent antileukaemic activity

Dalton Transactions

Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Organometallics

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

Journal of Advanced Research

DNA-binding, catalytic oxidation, CC coupling reactions and antibacterial activities of binuclear Ru(II) thiosemicarbazone complexes: Synthesis and spectral characterization

Journal of Inorganic Biochemistry

Approaching tumour therapy beyond platinum drugs

An efficient synthesis and in vitro antibacterial evaluation of ruthenium–quinolinol complexes

Journal	Data powered by TypesetBioorganic & Medicinal Chemistry Letters
Publisher	Data powered by TypesetElsevier BV
ISSN	0960-894X
Open Access	0