Staphylococcus is a natural inhabitant of the skin and nasal cavities of almost 30 percent of the healthy population. The Staphylococcus strains which have developed resistance towards penicillin-related drugs such as amoxicillin and methicillin are known as methicillin-resistant Staphylococcus aureus (MRSA). The emergence and various outbreaks of MRSA over the decades have made it difficult to combat antibiotic resistance with the current class of antibiotics. The major causes for prevalence of MRSA are the increasing hospital-associated bacterial infections (HA-MRSA), health care associated MRSA-patients with ongoing dialysis or chemotherapy and also community associated MRSAtransfer from human to human transmission. The present book chapter emphasizes the occurrence of MRSA in health care settings as well as community-based infections, the symptoms and diagnosis associated with MRSA infections, treatment and various mechanisms to combat methicillin resistant Staphylococcus aureus. © 2020 Nova Science Publishers, Inc.