The aim of the present study was to evaluate the analgesic, antipyretic and ulcerogenic effects of piperine, which is an active ingredient of pepper. Mice were administered piperine (20 and 30 mg/kg) intraperitoneally; hot plate reaction test and acetic acid test were used to determine the analgesic activity of piperine inmice. Antipyretic and ulcerogenic effects of piperine were also evaluated. It was found that piperine exhibits significant analgesic and antipyretic activities without ulcerogenic effects. The results were comparable with indomethacin which was used as standard drug for reference. The results thus obtained prove the analgesic effects of piperine showing its possible use in this regard however further studies are required to study the mechanism of piperine to confirm these activities.