The applications of light-emitting diodes as light source have been extended to photodynamic therapy, nerve stimulation, and optical biosensors. This requires the diodes to be implanted inside specifically targeted organs for sensing and therapy using flexible substrates as a system which are biocompatible. The proposed work focuses on determining the parameters to be evaluated for designing of flexible bioimplant for optogenetics study. © 2018, Springer Nature Singapore Pte Ltd.