Adaptation of information technology has leads to creation of several applications in health care informatics. Health care informatics is generating large amount of data. These data can be processed using data mining techniques to predict the diseases. Data mining is the process of analyzing, extracting data and furnishes the data as knowledge which forms the relationship within the available data. Some of the data mining techniques include association, clustering, classification and prediction. Various data mining tools are compared to analyze the performance of health care data and disease prediction. © 2017, Pharmainfo Publications. All rights reserved.