A major number of crimes dealt by forensic companies are drug related. A large number of crimes are related to unidentified substances which might be illegal drugs. The crime might involve death due to overdosing or abusing of drugs. It might not necessary be illegal drugs, it might also involve overdose of common over-the-counter (OTC) drugs like aspirin. In order to identify the reason for the death of a person or to catch individuals for the possession of illegal drugs, they need to be identified correctly by the forensic scientists. One technique used for identification of drugs is chromatography. It is a favored technique as it is simple to perform, easy to interpret and works for a large variety of drugs. We will be using paper chromatography technique for analyzing the common OTC painkillers. Some examples of painkillers that are abused are Tylenol, Anacin and Vicodin [5] but these drugs are most commonly not available without a prescription. Thus for the ease of the experiment we will be analyzing drugs which are easily available at medical stores without prescription like paracetamol, combiflam and disprin. The most of common active ingredients in OTC painkillers are aspirin, caffeine and acetaminophen. The substances mentioned above will be tested for the presence of the active ingredients aspirin and caffeine.