Acquired immunodeficiency syndrome could be an immunosuppressive disease (AIDS) that is produced through human immunodeficiency virus (HIV). AIDS is one of the main causes for death in Asia, Southeast Asia, and Sub Saharan Africa. Around the world, it’s fourth largest killer. Almost all of the marketed, medically useful anti-HIV drugs were nucleoside; however, there usage is limited because of the serious adverse effect, drug resistance, and toxicity. The most of the drugs for several ailment diseases undergo first pass metabolism, leading to drug inactivation and also the generation of toxic metabolites. Hence, herbal medicines are generally used for alternative therapy by people live with HIV. Natural products constantly provided a source of lead compound for most disease. Flavonoids which have strong anti-HIV activities had been discussed in this article. Flavonoids are common as well as distributed group of phenolic compounds, occurring in all plant parts. Flavonoid compounds describe an essential natural source of anti-retroviral for the AIDS therapy because of their significant anti-HIV 1 activity and also low toxicity. Numerous flavonoids possess the free radical scavenging capacity, anti-inflammatory, hepatoprotective, antioxidant and anticancer activities while someone exhibit antiviral activities. The purpose of the cur-rent review is reporting the latest findings, and updates to anti-HIV flavonoids from herbal products. © JK Welfare & Pharmascope Foundation.