Zika Virus (5IRE) is a single stranded RNA genome. Neem components like nimbin, nimbolide, catechin, gallic acid, gedunin, azadirachtin, mahmoodin, epicatechin, margolone, margolonone, ismoargolonone have better antiviral activity over zika virus. Neem has various other properties like anti-inflammatory, spermicidal, anti-arthritic, antipyretic, hypoglycemic, antiulcer, immunomodulatory, antifungal, antibacterial, diuretic, antimalarial. The library of ligands was taken from NCBI (National Centre for Biotechnology Information), and protein from RCSB Protein Data Bank. The top docked result for both agonist and antagonist was taken and their analogues were created and thus autodocking plays a vital role in drug discovery. © International Science Press.