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Antibacterial microemulsion prevents sepsis and triggers healing of wound in wistar rats
Published in Elsevier BV
2013
PMID: 23357738
Volume: 105
   
Pages: 152 - 157
Abstract
Microemulsions are thermodynamically stable isotropic systems comprising of oil, surfactant and water. Cinnamon oil (Cinnamomum zeylanicum) microemulsion was formulated using non-ionic surfactant Tween 20 and water. With oil to surfactant (v/v) ratio of 1:4, cinnamon oil microemulsion (CMF4) was formulated having droplet diameter of 5.79 and kinetically stable for 240 days. TEM images confirmed the spherical morphology of emulsion droplets. Surfactant concentration demonstrated a negative correlation with droplet diameter and turbidity but positive correlation with stability and viscosity. Formulated microemulsion (CMF4) was evaluated for bactericidal activity against . Staphylococcus aureus by dose and time dependent killing experiment. SEM analysis suggested that microemulsion treatment resulted in alteration of permeability and surface features of bacterial cell membrane which lead to lysis and cell death. CMF4 showed no erythema for skin irritation test in wistar rats and triggered wound-healing process in wistar rats. Control group without any treatment, cinnamon oil only and neomycin treated group healed in 20, 16 and 16 days, whereas cinnamon oil formulation (CMF4) treated group was healed in 14 days. © 2013 Elsevier B.V.
About the journal
JournalData powered by TypesetColloids and Surfaces B: Biointerfaces
PublisherData powered by TypesetElsevier BV
ISSN0927-7765
Open Access0
Authors (3)