Estimating Manning's roughness coefficient (n) is one of the essential factors in predicting the discharge in a stream. Present research work is focused on prediction of Manning's n in meandering compound channels by using the Group Method of Data Handling Neural Network (GMDH-NN) approach. The width ratio (α), relative depth (β), sinuosity (s), Channel bed slope (So), and meander belt width ratio (ω) are specified as input parameters for the development of the model. The performance of GMDH-NN is evaluated with two different machine learning techniques, namely the support vector regression (SVR) and multivariate adaptive regression spline (MARS) with various statistical measures. Results indicate that the proposed GMDH-NN model predicts the Manning's n satisfactorily as compared to the MARS and SVR model. This GMDH-NN approach can be useful for practical implementation as the prediction of Manning's coefficient and subsequently discharge through Manning's equation in the compound meandering channels are found to be quite adequate. © 2019 by the authors.