Aliovalent ion substituted hydroxyapatite of formulae BiNaCa3(PO4)3OH, Bi0.5M0.5Ca4(PO4)3OH (M&nbsp;=&nbsp;K, Ag) were synthesized and characterized. Antimicrobial properties of these synthesized materials were studied quantitatively by spread plate method against the microorganisms Escherichia coli (gram negative bacteria), Staphylococcus aureus (gram positive bacteria) and Candida albicans (yeast). Among the substituted hydroxyapatite compounds bismuth and silver substituted compound of formula Bi0.5Ag0.5Ca4(PO4)3OH shown excellent activity against all the three organisms. Cytotoxicity study was carried out against mouse fibroblast NIH-3T3 cell line in two different concentrations 10&nbsp;μg/mL and 20&nbsp;μg/mL by MTT assay method.

Sumathi S

Department of Chemistry

School of Advanced Sciences

Vellore Campus

Buvaneswari G

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

&nbsp;

&nbsp;

VIT University

Applied Surface Science

Cobalt ferrite nanoparticles have been synthesized by co-precipitation method using three different precipitating agents, viz. ammonium hydroxide, sodium hydroxide and monoethanolamine. The average particle size of the nanoparticles varied in the range 17-70 nm by varying the precipitating agents. The phase formation of the synthesized nanoparticles was performed via X-ray diffraction. Fourier infrared spectroscopy also confirmed the product formation. The microstructure and elemental composition were characterized by scanning electron microscopy and energy dispersive X-ray spectroscopy respectively. The precipitating agents were varied to vary the size and to study the effect of size on the morphology and antibacterial properties. The effect of precipitating agents and particle size on the antibacterial activity was carried out against the microorganism Staphylococcus aureus (gram positive bacteria) quantitatively by spread plate method. © 2015 Indian Ceramic Society.

Transactions of the Indian Ceramic Society

Synthesis, Characterization and Effect of Precipitating Agent on the Antibacterial Properties of Cobalt Ferrite Nanoparticles

Divalent ion (Cu, Co, Mn, Mg and Zn) substituted BiCa 4 (PO 4 ) 3 O (BCPO) – an apatite like oxyphosphate is synthesized by conventional high temperature solid state method and characterized by powder X-ray diffraction (XRD), Fourier Transform infrared spectroscopy (FT-IR), Thermogravimetric analysis (TGA), Scanning electron microscope (SEM) and Energy dispersive X-ray spectroscopy (EDAX). Antimicrobial properties of these synthesized materials are studied by spread plate method against the three organisms E.coli, S.aureus, and C.albicans. It is noticed from the results that Copper substitution improved the antibacterial activity of the oxyapatite compared to other divalent ion substitution. Cytotoxicity study is carried out by MTT assay method against fibroblast NIH 3T3 cell line. All the synthesized compounds are non-cytotoxic except Mn(II) and Zn(II) substituted oxyapatite.

Ceramics International

A new insight into biomedical applications of an apatite like oxyphosphate – BiCa4(PO4)3O

Copper substituted hydroxyapatite (Ca10-xCux(PO4)(6)(OH)(2) (x=0.05-2.0), and fluorapatite Ca10-xCux(PO4)(6)(F)(2) (x=0.05-2.0) were synthesized by co-precipitation method. The synthesized compounds were characterized by powder X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and thermo gravimetric analysis. The antimicrobial activity of the synthesized compounds were tested against the organisms Escherichia coli (Gram negative bacteria), Staphylococcus aureus (Gram positive bacteria) and Candida albicans (yeast) quantitatively by spread plate method. 100% reduction in the number of colonies were observed with Ca10-xCux(PO4)(6)(F)(2) (x=0.15-0.5) against E. colt. This material can be considered as good antibacterial agent for bone implantation.

Copper substituted hydroxyapatite and fluorapatite: Synthesis, characterization and antimicrobial properties

Mono, di and trivalent ions containing hydroxyapatite of the formula BiNaCa 3(PO 4) 3OH has been synthesized and the compound's catalytic activity in three component Biginelli condensation was studied. The compound was characterized by powder XRD, FT-IR, SEM and TGA/DTA techniques. The unit cell dimensions of the compound were determined to be a = 9.412(2) , C = 6.92(2) and the unit cell volume is 530.9 3. The substituted hydroxyapatite phase showed enhanced reactivity in the one pot synthesis of 3,4-dihydropyrimidin-2(1H)-one by Biginelli reaction and resulted in an increased yield of the product. © 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

Journal	Data powered by TypesetApplied Surface Science
Publisher	Data powered by TypesetElsevier BV
ISSN	0169-4332
Open Access	0