People are using this herb Convolvulus pluricaulis choisy for enhancing mind power-learning, memory and recall. Various toxicological evaluations of this herb have suggested that it is a relatively safe compound to treat many diseases. Anti-stress activity of aqueous extract of C. pluricaulis Choisy (Sankhapuspi) (AECP) was investigated against experimentally induced stress in rats using cold water forced swimming stress model in rats. Three doses 100 mg/kg body weight (bw), 150 mg/kg bw and 200 mg/kg bw of AECP was treated orally to the stress induced rats for the evaluation of anti-stress activity. The parameters like body weight measurement, lipid peroxidation and cortisol levels were estimated to determine the anti-stress activity. The stress induced animals post-treated with AECP-100, AECP-150 and AECP-200 mg/kg bw significantly restored the altered body weight and serum cortisol and lipid peroxidation levels, when compared with stress control group. The results of this research showed that the AECP showed a significant dose-dependent anti-stress activity due to its neuroprotective and antioxidant activity. © 2018 Pharmascope Publications. All rights reserved.