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Application of UV–Vis spectrophotometric process for the assessment of indoloacridines as free radical scavenger
, Prasad K.J.R, , Al-Dhabi N.A, Arasu M.V.
Published in Elsevier BV
2016
Volume: 162
   
Pages: 641 - 645
Abstract
A conventional approach has been used to synthesis Indole fused acridine, 4a–e. In this paper to achieve the target molecule, 4 the reaction was performed via two steps. In step 1, there was a reaction between Carbazolone, 1 and benzophenone, 2 to get dihydroindoloacridine, 3. In step 2, compound, 3 was treated with 5{\%} Palladium/Carbon in the presence of diphenyl ether for 5 h to give a dark brown product, 4. The column chromatography was used to purify final product, 4. All the synthesized compounds such as 3 and 4 were characterized by melting point, FTIR, 1H NMR and Mass spectra. Further to check the purity of the compounds it was subjected to CHN analyzer. The target molecules such as 3 and 4 were screened for antimicrobial studies against bacteria such as Bacillus subtilis (B. subtilis), Staphylococcus aureus (S. aureus), Klebsiella pneumonia (K. pneumonia), Salmonella typhi (S. typhi); and fungi like Aspergillus niger (A. niger), Aspergillus fumigatus (A. fumigatus). The obtained results clearly proves that the target molecules shown reasonable activity against K. pneumonia and A. niger. Further the compounds were screened for free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). The free radical scavenging property was performed using UV–Visible spectroscopy. The results were compared with the standard BHT (Butylated Hydroxy Toluene). Compounds, 4a and 4e were shown higher percentage of inhibition when compare to the standard. The result confirms that further research on indoloacridine will leads effective drug to the market.
About the journal
JournalData powered by TypesetJournal of Photochemistry and Photobiology B: Biology
PublisherData powered by TypesetElsevier BV
ISSN1011-1344
Open Access0