In this paper, we consider a class of abstract neutral integro-differential inclusions with infinite delay in Hilbert spaces. We establishes a set of sufficient conditions for the approximate controllability for a class of abstract neutral integro-differential inclusions with infinite delay in Hilbert spaces by using Bohnenblust-Karlin's fixed point theorem. An example is also given to illustrate our main results. © 2016 The authors. All rights reserved.