Kannabiran K

Department of Bio-Medical Sciences

School of Bio Sciences and Technology

Vellore Campus

Kumar saurav

Subhasish saha

Manoj singh

Soumik sarkar

Dharumadurai dhanasekaran

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Antimicrobials

Objective: Research of isolates producing antifungal activity. Material and methods: An actinomycetes strain having anti-Aspergillus activity against multidrug drug resistant clinical isolates was isolated from marine sediment samples collected at Marakkanam coast of Bay of Bengal, India. The strain was characterized by polyphasic taxonomic approach and identified as a member of the genus . Streptomyces. Based on the phenotypic and phylogenetic analysis, the strain was classified as a new species of the genus . Streptomyces and designated as . Streptomyces VITSVK5 spp. The G. +. C content of the isolated DNA is 71.3 mol% and the 16S rDNA sequence of the strain showed 93% similarity with . Streptomyces MSU2261. The media and growth conditions were optimized for maximal growth under shake flask conditions by measuring the dry weight of mycelium. Eleven multidrug resistant (MDR) . Aspergillus strains were isolated from sputum samples collected voluntarily from the pulmonary tuberculosis patients. Results: The isolated MDR strains showed the MIC value between 4-16μg/ml against the tested antifungal drugs, amphotericin B, itraconazole, ketoconazole and fluconazole. Ethyl acetate crude extract of . Streptomyces VITSVK5 spp. exhibited significant antifungal activity against MDR strains with the zone of inhibition ranging from 22 to 28. mm and the MIC value of 0.125-4μg/ml. Conclusion: The isolated . Streptomyces is a good candidate for the extraction and the purification of its antifungal metabolite. © 2010 Elsevier Masson SAS.

Journal de Mycologie Médicale

Antifungal activity of Streptomyces VITSVK5 spp. against drug resistant Aspergillus clinical isolates from pulmonary tuberculosis patients

ChemInform

ChemInform Abstract: Arthrichitin. A New Cell Wall Active Metabolite from Arthrinium phaeospermum.

Journal of Antimicrobial Chemotherapy

Clinical effectiveness of posaconazole prophylaxis in patients with acute myelogenous leukaemia (AML): a 6 year experience of the Cologne AML cohort

The Journal of Antibiotics

Microbial drug discovery: 80 years of progress

Antimicrobial Agents and Chemotherapy

Clinical Isolates of Aspergillus Species Remain Fully Susceptible to Voriconazole in the Post-Voriconazole Era

Aspergillosis and its resistance: Marine natural products as future treatment

Journal	Antimicrobials
Publisher	CRC Press
Open Access	0