This paper presents the performance of compressive strength of M40 Grade artificial sand concrete with partial replacement of river sand to manufactured/Artificial sand. This necessitates huge demand of concrete for infrastructure development worldwide and extreme scarcity of natural sand availability. Investigation carried out by varying 0 to 100% replacement of natural sand with manufactured sand in M40 mix. The concrete specimens were cured on normal moist curing under normal atmospheric temperature. The compressive strength was determined at 7, 14 and 28 days. M 40 Grade concrete using complete manufactured sand yielded an excesses strength of 7.65%, 7.76% and 2.71% compared to conventional concrete for 7 days, 14 days and 28 days respectively, with a reduction of -25.37% in slump. To improve the workability 0.5% of Cera-Chem plasticizer as admixture is recommended. Hence M40 Grade concrete with manufactured sand was found to increase the compressive strength of concrete on all ages when compared to conventional concrete with river sand. © 2006-2015 Asian Research Publishing Network (ARPN).