Recently Myosin 1H gene has been implicated in mandibular retrognathism. But the quantitative influence of Myosin 1H polymorphism on mandibular retrognathism is yet unexplored. This study was conducted to understand the role of Myosin 1H single nucleotide polymorphisms in mandibular retrognathism using South Indian Dravidian population as samples. Lateral cephalograms were obtained from retrognathic and normal individuals and related to genotype to study the power of association between them. Definite influence of gene make up is seen on muscle growth and in turn mandibular retrognathism but quantitative association could not be determined due to possible over shadowing influence of cybernetics. In future studies considering gene- environment interactions should be investigated to estimate the overall risk of a large sample size to clarify the association of MYO1H gene in causing true mandibular retrognathism. © 2019, Indian Journal of Public Health Research and Development. All rights reserved.