Biotransformation of chiral intermediates using micro-organism has widely used in many industries due to green technology and cost effectiveness. Moreover, Enzymes are highly ‘Chemo-, regio-, and enantio-selective’ in nature. From decades, bio-reduction performed using whole cells and free enzymes for the production of chiral alcohols. Some recent developments in the area of fermentative biotransformation processes for the reduction of Keto- sulfone to hydroxy sulfone and Lipitor intermediate are reviewed and importance of microbial mediated asymmetric synthesis of chiral alcohols are highlighted for the future perspective. © RJPT. All rights reserved.