Objective: Smart, Intelligent, Novel machinery has been automated for large scale production of collagen sheets. Methods: Collagen based wound dressing materials with required thickness in sheet form can be produced by the automated machinery. Moisture, pH, Temperature and IR sensors are interfaced with the ARM CORTEX microcontroller attached to the machinery. Low cost dryers are used to dry the wet sheet processed from the developed machinery. The use of social network like the GSM are also used in the machinery Results: There is further improvement in the drying time of the paste to sheet form, compared to our earlier study. The drying time of the sheet from this process is 60 min and the sheets exhibit good tensile strength compared to our earlier study. The collagen sheets produced have a thickness of ≤ 1mm and a width of 250mm. Conclusion: The operator is provided information of the pH, Moisture, and temperature of the sample paste. The machinery automatically notifies the operator about the completion of the process through GSM.