The significance of Azithromycin (AZ) on corrosion of aluminium alloy 2024 in 0.1N Hydrochloric acid was examined using weight loss measurements, Tafel polarization studies and scanning electron microscopy. The results indicated that AZ is a good inhibitor for aluminium alloy in 0.1N HCl and maximum efficiency obtained was 91% at 450ppm concentration of azithromycin. Potentiostatic Polarization analyses displayed that AZ works as a mixed type of inhibitor. Electrochemical impedance plots were used to examine the mechanism of corrosion. Quantum chemical studies were done for azithromycin and its various quantum chemical parameters were calculated and tabulated. © 2014 University of Manchester and the authors.