Background: Hepatitis B is a disease which has caused major loss of life over the years. The treatment for the disease is very expensive and cure rate is less. Due to its high cost developing or underdeveloped countries are far out of reach from treatment to hepatitis B. There are vaccines produced against this disease but its cost has limited the use by the masses. In the recent years the plant based vaccines called edible vaccines which are cheap compared to the traditional vaccines have been current area of research. Objective: Edible vaccines using banana have been prepared for Hepatitis B but in this hypothetical paper we have put forward our idea on preparing edible banana vaccine for Hepatitis B thorough a different methodology. Theoretical Model: We hypothesised to increase the expression level of the transgene by using pBIN19 as a vector instead of traditional Agrobacterium Ti plasmid. The paper also focuses on mechanism of the mode of action of vaccine along with advantages, disadvantages, challenges and future prospects of edible banana vaccine. © 2016 Bentham Science Publishers.