Entrepreneurship is becoming a popular term. At the same it is not possible for everyone to become successful in doing business. People with disabilities can also start their business. They are stressed to compete with the normal people. Differently abled people can successfully run their business. These people encounter with numerous physical and mental challenges and barriers to their business environment such as shortage of funding, lack of self-management, lack of experience and so on. This paper highlights about the barriers faced by the differently abled entrepreneurs in Sivaganga districts. Through factor analysis, five factors were explored such as financial barriers, skill-based barriers, perceptional barriers, motivational barriers and individual barriers. © IJSTR 2020.