The aim of the present investigation was to screen the bioactivity of Streptomyces sp. VITJS9 strain isolated from Kanyakumari, South East coast of India. The morphological, physiological, biochemical and phylogenetic properties of the strain was confirmed by conventional methods. The ethyl acetate crude extract tested for antibacterial activity showed better zone of inhibition at 30 mg/ml concentration against bacterial pathogens. In DPPH scavenging assay the IC50 value of the crude extract was found to be 150 lg/ml and showed cytotoxic effect with IC50 of 125 lg/ml on HeLa cells. The GC–MS analysis revealed the presence of three major chemical constituents namely N-Hexadecanoic acid, Octadecanoic acid and Dimethylsulfoxonium formylmethylide. © The National Academy of Sciences, India 2015.

Subathradevi C

Department of Biotechnology

School of Bio Sciences and Technology

Vellore Campus

Mohanasrinivasan V

Department of Bio-Medical Sciences

Jemimah Naine S

Vaishnavi B.

Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

National Academy Science Letters

Over the past two decades, fungal infections have increased significantly and have been associated with increased morbidity and mortality. As advances in medical care have improved the survival of patients with severe and life-threatening illnesses, the more aggressive nature of such care has led to a rapid increase in the number of immunosuppressed populations. These changes have been correlated with a substantial increase in the rate of invasive fungal infections, mainly resulting from the rapid increase in the number of at-risk patients. Despite the remarkable progress in antifungal drug research in the past decade, difficulty in prompt treatment along with the complexity of the clinical characteristics of at-risk patients continues to make it a great challenge for the healthcare workers and researchers. The most commonly recognized causes of opportunistic invasive fungal infections traditionally are Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. Along with the widespread use of antifungal prophylaxis, the epidemiology of infection has shifted toward nonalbicans Candida, nonfumigatus Aspergillus, opportunistic yeastlike fungi (e.g., Trichosporon and Rhodotorula spp.), Zygomycetes, and hyaline molds (e.g., Fusarium and Scedosporium spp.). These new and emerging fungi are characterized, and they exhibit greater resistance to standard antifungal drugs. Invasive fungal infections due to these previously rare fungi are also more difficult to diagnose and are associated with even higher mortality rates. © 2016 by Taylor and Francis Group, LLC.

Antimicrobials: Synthetic and Natural Compounds

Antimicrobials

International Journal of Biological and Chemical Sciences

In vitro antibacterial activity of diterpene and benzoxazole derivatives from Excoecaria agallocha L.

Marine Drugs

Correction: Hong, K. et al. Actinomycetes for Marine Drug Discovery Isolated from Mangrove Soils and Plants in China. Mar. Drugs 2009, 7, 24–44

Bioinformation

Phylogenetics of an antibiotic producing Streptomyces strain isolated from soil

European Journal of Haematology

Effects of arsenic trioxide (As2O3) on leukemic cells from patients with non-M3 acute myelogenous leukemia: studies of cytotoxicity, apoptosis and the pattern of resistance

Bioactive Potential of Marine Derived Strain Streptomyces brasiliensis VITJS9 Isolated from South East Coast of Tamil Nadu, India

Journal	Data powered by TypesetNational Academy Science Letters
Publisher	Data powered by TypesetSpringer Science and Business Media LLC
ISSN	0250-541X
Open Access	No