In the current study, anaerobic digestion method efficiency on biogas production and chemical oxygen demand (COD) degradation was assessed through a sequence of laboratory-scale batch experimentations to compute the role of chosen process parameters, viz., solid concentration (5–15%), pH (5–9), temperature (30–60 °C), and co-digestion (0–40% of poultry manure). Biogas production and COD degradation were significantly dependent on the selected process parameters with independent conditions to accomplish active performance of the process. Central composite design (CCD)-based response surface methodology (RSM) was adopted for evaluation and optimizing of the combined performance of system considering two responses. Among various combinations, it was observed that solid concentration of 7.38%, pH value as 7, temperature at 48.43 °C, and co-digestion as 29% produce biogas of 6344 ml and COD degradation as 38%. Confirmation experiment performed shows a deviation of 4.93% maximum between the predicted and experimental results. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.