In this research paper, the biomedical optical analytical techniques such as ultra-violet spectroscopy, Fourier transform infrared spectroscopy and Fourier transform-Raman spectroscopy are used to characterise and quantise the medicinal drugs. The hydroxyl group and methyl group was assigned to the wave numbers 3230.67 cm-1 and 2928.50 cm-1. The functional groups are also identified -N=C=O, -N=C=S, -N=C=N-, -N3 at 4.67 μm. The CH, CH2, and CH3 three bands with strong intensity are assigned to the wave numbers 2985 cm-1 to 2850 cm -1. The FT-Raman spectra is obtained for the blue sample, the functional group C=C is assigned to the wave number 2129.84 to 2191.41 cm -1. The wave numbers 2558.71-2620.73 cm-1 are obtained for the functional bond -S-H. The wave number 1610.95 cm-1 is obtained for the C=N functional group. In this paper one sample namely Fibril-SF is taken by a patient and his Saliva sample is collected for Fourier Transform Infrared spectroscopy test to analyse the reaction of drugs with human body tissues. Copyright © 2013 Inderscience Enterprises Ltd.