(Please read carefully abstract of the template). Giving anesthesia in operating rooms is generally a practice of making patients unconsciousness and ensuring safe surgery to the patients. Some of the procedures are fixed, few are predefined and some need patient response to alter the anesthetic drugs infusions to reach the required hemodynamic values. The automation in drug delivery will minimize the distractions of anesthetist and he can spend more time for direct care of patient. In the view of automatic drug delivery system, developing the relationship between depth of anesthesia and the delivery of intravenous anesthetic drugs is important. This article discuss about these relationship and defined Simulink model for the same. The results are taken based on the BIS score. This score is compared with target value, the tolerance percentage levels of reaching the target value is discussed for both male and female patients. ©BEIESP.