Objective: Most species have their trademark metabolites or a class of chemicals that are generally disseminated inside the genus variety. Secondary metabolites from the black turmeric are predominantly camphor, terpenes, lactones, alkaloids, and phenols classification. A database was constructed with the predicted absorption, distribution, metabolism, elimination, and toxicity, druglikeliness, and physiochemical properties of the exclusive black turmeric 103 compounds. Methods: The interface has been designed using Microsoft Structured Query Language platform, keeping in mind the ease of use for a researcher. To support this, the entire set of chemicals and their properties was uploaded in database. Database is used as it is very efficient and supports multiple users at the same time.Results: Black turmeric database gives complete data of compounds by means of 4 segments. Physiochemical, pharmacodynamics, pharmacokinetics, druglikeliness, and molecular information are displayed with chemical structure.Conclusion: We solidly believe that the information from this database are the sources to infer novel pharmaceutical chemical compounds for medication.

Patel Trupti Navinchandra

Department of Integrative Biology

School of Bio Sciences and Technology

Vellore Campus

Mukunthan K.S

Balaji B

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Vellore Institute of Technology (VIT) is a private university located in&nbsp;Tamil Nadu, India. Founded in 1984, as Vellore Engineering College, the institution offers 20 undergraduate, 34 postgraduate, four integrated and four research programs. It has campuses in Vellore, Amravati, Bhopal and Chennai.

VIT is one of the top ranked private universities in India according to NIRF, THE and QS Rankings.&nbsp;Govt. of India has recognized&nbsp;VIT, Vellore as an&nbsp;Institution of Eminence. This has allowed VIT to take independent quality initiatives and move up in world ranking.

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VIT University

Asian Journal of Pharmaceutical and Clinical Research

Curcuma caesia Roxb. (Black turmeric), a perennial herb of the family Zingiberaceae is indigenous to India. C. caesia is used as a spice, food preservative and coloring agent commonly in the Indian subcontinent. Functional parametric pharmacological evaluations like drug ability and toxicity profile of this endangered species is poorly documented. In our present study, among all the extracts of dried C. caesia rhizome viz- hexane, ethyl acetate, methanol and water tested for free radical scavenging capacity by total antioxidant activity (TAO) method, Hexane Rhizome Extract (HRE) was found to possess remarkable activity (1200 mg ascorbic acid equivalent/100 g). In MTT assay across three cancer cell lines and a control cell line, HRE exhibited a dose-dependent inhibition only in cancer cells, with notable activity in HepG2 cell lines (IC50: 0976 µg/mL). Further, western blotting and flow cytometry experiments proved that HRE induces cell arrest at G2/M phase along with cellular apoptosis as suggestive by multiple-point mitochondrial mediated intrinsic pathway of Programmed Cell Death (PCD). Gas Chromatography-Mass Spectrophotometry (GC-MS) analysis of HRE suggested twenty compounds that when docked in silico with Tubulin (1SA0) and Epidermal Growth Factor Receptor/ EGFR (1XKK) showed very intimate binding with the original ligands. Our results provided significant evidence of the toxicity mechanisms of HRE that may be beneficial for more rational applications of drug discovery for slowing down cancer progression. © 2017 Elsevier Ireland Ltd

Journal of Ethnopharmacology

Pharmacological evaluation of phytochemicals from South Indian Black Turmeric ( Curcuma caesia Roxb.) to target cancer apoptosis

ABSTRACTObjective: Aim of this study is to analyze the antibacterial and antioxidant potential of crude saponin extract (CSE) from Abutilon indicum leaves.Methods: CSE was subjected for gas chromatography-mass spectrometry (GC-MS) analysis to identify its components. Antibacterial potentialwas analyzed using agar well diffusion method and minimum inhibitory concentration (MIC) was detected using 96-well plate method, againstStaphylococcus aureus (MTCC: 3160) and Escherichia coli (MTCC: 443). DNA damage study was performed using comet assay. Antioxidant capabilitywas studied using 2,2-diphenyl-1-picrylhydrazyl scavenging assay.Results: GC-MS analysis suggested a library match to benzene-1-4-bis(phenylmethyl), with a molecular weight of 258 g/mol to be the majorcomponent in the CSE at 21.25 RT. CSE demonstrated 96.16% free radical scavenging activity at 2.5 mg/ml concentration. CSE demonstrateda significant antibacterial activity in the well diffusion assay, S. aureus 17 mm and E. coli 15 mm, with a MIC value of 1.11 mg/ml. Comet assaydemonstrated no DNA damage.Conclusion: These results conclude that CSE of A. indicum leaves possesses promising antibacterial and antioxidant potential.Keywords: Abutilon indicum, Saponin, Escherichia coli, Staphylococcus aureus, 2,2-diphenyl-1-picrylhydrazyl, Antibacterial assay.

ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF SAPONIN FROM ABUTILON INDICUM LEAVES

Abstract: The essential oil extracted by hydro-distillation from rhizome of Curcuma caesia Roxb. grown in southern India were analyzed by gas chromatography and gas chromatography–mass spectrometry. A total of 35 volatile essential oil components were identified in the extracted oil of C. caesia representing tropolone (15.86 %) as major compound, ledol (3.27 %), β-elemenone (3.03 %) and α-bulnesene (3.02 %), spathulenol (2.42 %) as minor compounds and borneol (0.85 %), α-terpineol (0.77 %), eucalyptol (0.62 %), caryophyllene (0.45 %) as trace compounds. The results from our analysis indicated that levels of sesquiterpene (62.8 %) were more than those of monoterpene components (1.4 %). © 2014, Har Krishan Bhalla &amp; Sons.

Journal	Asian Journal of Pharmaceutical and Clinical Research
Publisher	Innovare Academic Sciences Pvt Ltd
ISSN	0974-2441
Open Access	Yes