Radio Frequency Identification (RFID) is an automatic data capturing technology and the dirty data stream generated by the RFID readers is one of the main factor limit the widespread adoption of RFID technology. In order to provide reliable data to RFID application, it is necessary to clean the collected data before they are subjected to warehousing. In this paper we are going to construct the elegant hospital environment using RFID and developed the cellular based approach algorithm to clean the duplication anomaly. First middleware approach is applied to deal with low complex anomalies and in next stage deferred approach is followed to deal with high complex anomalies based on business context. Simulation shows our cleansing approach for duplication removal deals with RFID data more accurately and efficiently. Thus we can bring down the health care costs, optimize business processes, streamline patient identification processes and improve patient safety. © 2013 Springer Science+Business Media.