Computational Fluid Dynamics analysis has emerged as a necessary tool for designing of turbomachinery. It helps to understand the various sources of inefficiency through investigation of flow physics of the turbine. In this paper, 3D turbulent flow analysis of a cryogenic turboexpander for small scale air separation was performed using Ansys CFX®. The turboexpander has been designed following assumptions based on meanlineblade generation procedure provided in open literature and good engineering judgement. Through analysis of flow field, modifications and further analysis required to evolve a more robust design procedure, have been suggested. © 2015 The Authors.