The present study investigated the weldability of dissimilar metals involving Inconel 625 and Super-duplex stainless steel obtained from continuous current (CC) and pulsed current (PC) gas tungsten arc welding (GTAW) processes employing ER2553 and ERNiCrMo-4 fillers. A comparative analysis on these dissimilar weldments was carried out to establish the structure-property relationships. Microstructure examination was carried out using optical microscopy (OM) and scanning electron microscopy (SEM) techniques. Grain coarsening was observed at the HAZ of UNS S32750 for all the cases. Mechanical tests ascertained that the PCGTA weldments employing ERNiCrMo-4 offered better weld strength and impact toughness. Elaborative studies on the structure – property relationships of these dissimilar weldments were discussed.